Boehringer Ingelheim to start late-stage hepatitis C drug trial

BOSTON (Reuters) – Boehringer Ingelheim said on Saturday it plans to initiate a late-stage clinical trial of its experimental hepatitis C treatment following promising results from earlier studies.

The company announced final data from a mid-stage trial of its treatment regimen which showed that 69 percent of patients in the study were free of the virus 12 and 24 weeks following the end of treatment.

Hepatitis C is a blood-borne infectious disease of the liver that can lead to liver failure and transplant.

Historically, hepatitis C has been treated with pegylated interferon and ribavirin, but treatment lasts as long as 48 weeks and interferon is associated with flu-like side effects.

The goal of drugmakers now, including Boehringer, Vertex Pharmaceuticals Inc, Gilead Sciences Inc and Bristol-Myers Squibb Co is to develop products that do not need to be combined with interferon. Most analysts consider Gilead to currently be at the forefront of the race.

Full results from Boehringer’s trial, known as SOUND-C2, were presented at the annual meeting of the American Association for the Study of Liver Diseases in Boston. Preliminary data were presented earlier this year.

Boehringer’s trial tested a combination of BI-201335, a protease inhibitor, BI-207127, a polymerase inhibitor, and ribivirin.

Boehringer is a privately held company headquartered in Ingelheim, Germany.

(Reporting By Toni Clarke; Editing by Marguerita Choy)

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FBI probe of Petraeus began with 'suspicious emails'

WASHINGTON (Reuters) - The FBI investigation that led to the discovery of CIA Director David Petraeus' affair with author Paula Broadwell was sparked by "suspicious emails" that initially did not contain any connection to Petraeus, U.S. law enforcement and security officials told Reuters on Saturday.

But the CIA director's name unexpectedly turned up in the course of the investigation, two officials and two other sources briefed on the matter said.

It was "an issue with two women and they stumbled across the affair with Petraeus," a U.S. government security source said.

The Washington Post reported on Saturday that the FBI probe was triggered when Broadwell sent threatening emails to an unidentified woman close to the CIA director.

The woman went to the FBI, which traced the threats to Broadwell and then uncovered explicit emails between Petraeus and Broadwell, the Post said.

Attempts by Reuters and other news media to reach Broadwell, an Army reserve offer and author of a biography of Petraeus, have not been successful.

The FBI and CIA declined comment on Saturday.

Many questions in the case remain unanswered publicly, including the identity of the second woman; the precise nature of the emails that launched the FBI investigation; and whether U.S. security was compromised in any way.

Nor is it clear why the FBI waited until Election Day to tell U.S. Director of National Intelligence James Clapper, who oversees the CIA and other intelligence agencies, about its investigation involving Petraeus.

The CIA director announced his resignation suddenly on Friday, acknowledging an extramarital affair and saying he showed "extremely poor judgment.

The developments likely ended the public career of one of the United States' most highly regarded generals, who was credited with helping pull Iraq out of civil war and led U.S. and NATO troops in Afghanistan.

Meanwhile, new details emerged on Saturday about developments in the final days leading to Petraeus' departure from atop the CIA.

Clapper was notified by the FBI on Tuesday evening about 5 p.m. - just as returns in the U.S. presidential election were about to come in - about "the situation involving Director Petraeus," a senior intelligence official said. Clapper and Petraeus then spoke that evening and the following morning.

WHITE HOUSE NOTIFIED WEDNESDAY

"Director Clapper, as a friend and a colleague and a fellow general officer, advised Director Petraeus that he should do the right thing and he should step down," the official said.

Clapper is a retired Air Force lieutenant general; Petraeus served nearly four decades in the U.S. Army.

On Wednesday, Clapper notified the National Security Council at the White House that Petraeus was considering resigning and President Barack Obama should be informed, the official said.

U.S. law enforcement and intelligence officials agreed to discuss the Petraeus matter only on condition of anonymity because of the issue's sensitivity and because it is the subject of a law enforcement investigation.

Once Petraeus' name turned up in the investigation, the importance of the FBI inquiry was immediately escalated, as investigators became concerned the CIA chief somehow might have been compromised, the law enforcement official said.

However, the official and two sources briefed on the matter said no evidence has turned up suggesting Petraeus had become vulnerable to espionage or blackmail. At this point, it appears unlikely that anyone will be charged with a crime as a result of the investigation, the official said.

The FBI investigation began fairly recently - months ago rather than years ago, when Petraeus would still have been in uniform as one of the U.S. Army's top field commanders, the official said.

Representative Peter King, Republican chairman of the House of Representatives' Homeland Security Committee, said in an interview on MSNBC the FBI was "investigating or monitoring ... the director of the CIA for four or five months."

Several officials briefed on the matter said senior officials at the Pentagon, CIA and Congress knew nothing of the FBI's investigation of Petraeus until Thursday afternoon at the earliest, and some key officials were not briefed on the details until Friday.

There is no evidence at this time that anyone at the White House had knowledge of the situation involving Petraeus prior to the U.S. presidential election on Tuesday, which saw Obama elected to a second four-year term.

Another U.S. government security source said it was not until Friday afternoon that some members of the House and Senate intelligence oversight committees were notified about Petraeus' resignation by Clapper's office.

The congressional committees were told that it was a personal issue that Petraeus had to discuss with his wife. When pressed, a representative of the Office of the Director of National Intelligence said it involved another woman.

(Writing by Warren Strobel; Additional reporting by Doug Palmer and Matt Spetalnick; Editing by Todd Eastham)

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Syria opposition bloc elects Christian as leader

DOHA, Qatar (AP) — Syria‘s main opposition group in exile has elected a Christian Paris-based former geography teacher as its new president.

George Sabra said Friday that his election as head of the Syrian National Council is a sign that the opposition is not plagued by sectarian divisions.

Sabra says the SNC‘s main demand is to receive weapons from the international community. The U.S. and some other foreign backers of rebels fighting the regime of President Bashar Assad have so far refused to send weapons for fear they can fall into the wrong hands.

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Spotify to raise $100 million at $3 billion valuation – report

(Reuters) – Spotify is in the middle of a $ 100 million financing round that could value the music streaming company at just over $ 3 billion, the Wall Street Journal reported citing sources.

The Journal said Spotify would raise the fresh capital from multiple investors including Goldman Sachs. The WSJ report did not name any other investors.

Spotify has raised capital from outside investors several times since it set up shop in 2006, and was earlier reported to have been looking to secure a capital boost of about $ 200 million, at a valuation of about $ 4 billion.

Kleiner Perkins Caufield & Byers, Accel Partners and others have invested about $ 189 million in the company in its prior financing rounds.

The company has over 15 million active users and 4 million paying subscribers, for its on-demand service, which offers unlimited music streaming of some 18 million tracks.

(Reporting by Himank Sharma in Bangalore)

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Philip Roth says he’s done writing

NEW YORK (AP) — Exit, Philip Roth? Having conceived everything from turning into a breast to a polio epidemic in his native New Jersey, Roth has apparently given his imagination a rest.

The 79-year-old novelist recently told a French publication, Les inRocks, that his 2010 release “Nemesis” would be his last. Spokeswoman Lori Glazer of Houghton Mifflin Harcourt said Friday that she had spoken with Roth and that he confirmed his remarks. Roth’s literary agent, Andrew Wylie, declined comment.

Roth certainly produced, completing more than 20 novels over half a century and often turning out one a year. He won virtually every prize short of the Nobel and wrote such classics as “American Pastoral” and “Portnoy’s Complaint.”

His name will remain on new releases, if only because the Library of America has been issuing hardcover volumes of his work. Roth also is cooperating with award-winning biographer Blake Bailey on a book about his life.

The author chose an unexpected forum to break the news, but he has been hinting at his departure for years. He has said that he no longer reads fiction and seemed to say goodbye to his fictional alterego, Nathan Zuckerman, in the 2007 novel “Exit Ghost.”

Retirement is rarely the preferred option for writers, for whom the ability to tell stories or at least set down words is often synonymous with life itself. Poor health, discouragement and even madness are the more likely ways literary careers end. Roth apparently is fit and his recent novels had been received respectfully, if not with the awe of his most celebrated work.

“I don’t believe it,” Roth’s friend and fellow writer Cynthia Ozick said upon learning the news. “A writer who stops writing while still breathing has already declared herself posthumous.”

His parting words from “Nemesis”: “He seemed to us invincible.”

Roth’s interview appeared in French and has been translated, roughly, by The Associated Press. He tells Les inRocks that “Nemesis” was “mon dernier livre” (“My last book”) and refers to “Howard’s End” author E.M. Forster, and how he quit fiction in his 40s. Roth said he doesn’t plan to write a memoir, but will instead go through his archives and help ensure that Bailey’s biography comes out in his lifetime.

Explaining why he stopped, Roth said that at age 74 he became aware his time was limited and that he started re-reading his books of the past 20-30 years, in reverse order. He decided that he agreed with what the boxer Joe Louis had said late in life, that he had done the best he could with what he had.

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Was Petraeus affair linked to lax Libya response?

CIA Director David Petraeus abruptly resigned Friday, citing an extramarital affair and the need to sort out the “personal and professional issues” involved.

The former commander of forces in Iraq and Afghanistan had built a stellar and nearly unassailable reputation – but mounting criticism of the Central Intelligence Agency’s response to the Benghazi, Libya, terrorist attack in September was beginning to tarnish that reputation.

Word of Mr. Petraeus’s resignation sent ripples of stunned surprise through both the intelligence and military communities, raising questions that revolved around how long the affair had been going on and how an officer known for his rigorous self-discipline – and attention to his reputation within the media — could have made such a lapse in judgment.

RECOMMENDED: 5 ways events overseas could shape Obama's second term

In a letter of resignation accepted by the White House, Petraeus said he had been married 37 years but had exercised “very poor judgment” in choosing to enter into an extramarital affair.

Petraeus, who was widely celebrated as a military commander and even occasionally mentioned as a potential presidential candidate, was sworn in as head of the CIA in September 2011 – and had kept a low profile since. Now speculation is sure to proliferate over whether that low profile resulted from Petraeus focusing on America’s intelligence gathering or on personal matters.

In particular, members of Congress and other officials demanding answers about the Benghazi attack on the US consulate that resulted in the deaths of four Americans – including the US ambassador to Libya, Christopher Stephens, and two CIA agents – will want to know if there was any link between Petraeus’s extramarital activities and what has been increasingly criticized as the CIA’s weak performance on the night of the Benghazi attack.

More broadly, the reason for Petraeus’s departure will raise questions about any compromising of US covert operations and intelligence. The potential for blackmail of intelligence officers is always a concern about the spy corps, but the involvement of the nation’s top spy in an extramarital affair takes the concern to a new level.

The Federal Bureau of Investigation has been probing Petraeus and the potential security risks posed by his affair, CNN reported late Friday afternoon.

In the weeks since the Benghazi attack, officials have leaked information, including how Petraeus kept information on the CIA’s role in Benghazi so private that even Secretary of State Hillary Rodham Clinton was left to call Petraeus as the attack unfolded to try to get intelligence information from him.

Last week, CIA officials revealed that in fact, the intelligence agency’s operations in Benghazi dwarfed diplomatic operations at the consulate and that the CIA maintained what was described as an “annex,” about a mile from the diplomatic mission.

State Department officials have said there was an informal understanding that the annex and its agents would come to the assistance of the consulate (which had private contractors providing security) if a need arose. CIA officials insist their agents responded to the consulate’s distress calls within a half-hour.

In a statement released Friday afternoon, President Obama praised Petraeus for his “extraordinary service” to the country, adding, “By any measure, through his lifetime of service, David Petraeus has made our country safer and stronger.”

In a statement, Sen. John McCain (R) of Arizona highlighted Petraeus’s role in Iraq, saying that his “inspirational leadership and his genius were directly responsible – after years of failure – for the success of the surge in Iraq.”

But Petraeus’s success in Iraq and Afghanistan was a result to a certain extent of his focus on a counterinsurgency strategy that involved large numbers of troops fighting the enemy by incorporating nation-building into the battle. When Mr. Obama named Petraeus to head the CIA, it was widely interpreted as the president’s signal that he intended to wind down America’s wars and shift from a counterinsurgency strategy to counterterrorism.

Obama did not cite Petraeus’s reason for resigning but did say, “Going forward, my thoughts and prayers are with Dave and Holly Petraeus, who has done so much to help military families through her own work. I wish them the very best at this difficult time.”

Mrs. Petraeus is the assistant director of the Consumer Financial Protection Bureau, where she supports veterans and troops facing difficulties as a result of the financial crisis.

Obama initially tried to convince Petraeus not to resign, according to some souces. “I am told that President Obama tried to talk Petraeus out of resigning, but Petraeus took the samurai route and insisted that he had done a dishonorable thing and now had to try to balance it by doing the honorable thing and stepping down as CIA director,” Tom Ricks reports in his blog “The Best Defense.”

Such a move is in keeping with the military culture in which Petraeus rose to the rank of four-star general.

Under the Uniform Code of Military Justice, adultery is a punishable offense for soldiers if the conduct is shown to be detrimental “to good order and discipline in the armed forces or was of a nature to bring discredit upon the armed forces.”

Obama said that Michael Morell, deputy director of the CIA, would take over as acting director. Mr. Morell served briefly as acting director after Leon Panetta left the agency last year to become Defense secretary.

Petraeus was set to testify Thursday at a closed-door session of the Senate Intelligence Committee on the Benghazi attack, but it was unclear if his resignation would alter that schedule.

Sen. Dianne Feinstein (D) of California, the Intelligence Committee chair, told NBC News that Petraeus’s personal mistake should not have led to his resignation.

“I would have stood up for him,” she said. “I wanted him to continue. He was good, he loved the work, and he had a command of intelligence issues second to none.”

Obama, after winning reelection Tuesday, was already expected to make some changes in his national security team for a second term, but early speculation had been that Petraeus would stay on at the CIA. Now the job of spy chief will be added to the new-team mix.

RECOMMENDED: 5 ways events overseas could shape Obama's second term

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Myanmar says Obama to visit later this month

YANGON, Myanmar (AP) — President Barack Obama will make a groundbreaking visit later this month to Myanmar, an official said Thursday, following through with his policy of rapprochement to encourage democracy in the Southeast Asian nation.

The Myanmar official speaking from the capital, Naypyitaw, said Thursday that security for a visit on Nov. 18 or 19 had been prepared, but the schedule was not final. He asked not to be named because he was not authorized to give information to the media.

The official said Obama would meet with opposition leader Aung San Suu Kyi as well as government officials including reformist President Thein Sein.

It would be the first-ever visit to Myanmar by an American president. U.S. officials have not yet announced any plans for a visit, which would come less than two weeks after Obama’s election to a second term.

Obama’s administration has sought to encourage the recent democratic progress under Thein Sein by easing sanctions applied against Myanmar’s previous military regime.

Officials in nearby Thailand and Cambodia have already informally announced plans for visits by Obama that same week. Cambodia is hosting a summit meeting of the Association of Southeast Asian Nations, and Thailand is a longtime close U.S. ally.

The visit to Myanmar, also known as Burma, would be the culmination of a dramatic turnaround in relations with Washington as the country has shifted from five decades of ruinous military rule and shaken off the pariah status it had earned through its bloody suppression of democracy.

Obama’s ending of the long-standing U.S. isolation of Myanmar’s generals has played a part in coaxing them into political reforms that have unfolded with surprising speed in the past year. The U.S. has appointed a full ambassador and suspended sanctions to reward Myanmar for political prisoner releases and the election of Nobel laureate Suu Kyi to parliament.

From Myanmar’s point of view, the lifting of sanctions is essential for boosting a lagging economy that was hurt not only by sanctions that curbed exports and foreign investment, but also by what had been a protectionist, centralized approach. Thein Sein’s government has initiated major economic reforms in addition to political ones.

A procession of senior diplomats and world leaders have traveled to Myanmar, stopping both in the remote, opulent capital city, which was built by the former ruling junta, and at Suu Kyi’s dilapidated lakeside villa in the main city of Yangon, where she spent 15 years under house arrest. New Zealand announced Thursday that Prime Minister John Key would visit Myanmar after attending the regional meetings in Cambodia.

The most senior U.S. official to visit was Hillary Rodham Clinton, who last December became the first U.S. secretary of state to travel to Myanmar in 56 years.

The Obama administration regards the political changes in Myanmar as a marquee achievement in its foreign policy, and one that could dilute the influence of China in a country that has a strategic location between South and Southeast Asia, regions of growing economic importance.

But exiled Myanmar activists and human rights groups are likely to criticize an Obama visit as premature, rewarding Thein Sein before his political and economic reforms have truly taken root. The military — still dominant and implicated in rights abuses — has failed to prevent vicious outbreaks of communal violence in the west of the country that have left scores dead.

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Dancing With The Stars Family Rallies On Twitter In Support Of Brooke Burke-Charvet Following Thyroid Cancer Diagnosis

Members of the “Dancing with the Stars” family Tweeted their well-wishes for the show’s co-host, Brooke Burke-Charvet, who revealed on Thursday she has thyroid cancer.

Helio Castroneves, who was recently eliminated from the “All-Stars” season, said he is confident she will overcome the disease.

PLAY IT NOW: Brooke Burke-Charvet’s Sexy Lingerie Shoot!

“Hi @brookeburke, I have sure that you will win this battle. My affection for you,” the Indy driver wrote.

Brooke revealed on Thursday that she will be undergoing thyroid surgery and a thyroidectomy, and Erin Andrews, who competed in Season 10, noted she was praying for the host.

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“Thinking about @DancingABC friend @brookeburke..Prayers and all the best your way Brooke,” Erin wrote.

Also sending her kind words was Sabrina Bryan, who was eliminated last week on the show.

“@brookeburke hey girl!! You’re in my thoughts and prayers! Always here for you during this fight! Stay strong,” Sabrina wrote.

VIEW THE PHOTOS: Dancing With The Stars: All-Stars — Week 6

Season 13 vet Ricki Lake wrote, “@brookeburke sending huge healing love your way.”

Current contender Melissa Rycroft shared her support, Tweeting, “You’re such a strong woman, and I admire your courage. I hope you feel all the love and support behind you…We love you!”

VIEW THE PHOTOS: ‘Dancing’s’ Derek Hough

And some of the professional dancers chimed in too.

Pro Derek Hough (Brooke’s Season 7 partner) Tweeted, “Love you Brookie B. [You're] in my prayers.”

Cheryl Burke Tweeted, “I love u @brookeburke!! Stay strong. Will be praying for u and sending u lots of positive energy!”

– Jolie Lash

Copyright 2012 by NBC Universal, Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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VP Joe Biden guest stars as celebrity crush on “Parks and Rec”

LOS ANGELES (Reuters) – Someone has a big crush on U.S. Vice President Joe Biden – and now she is getting to meet him.

Biden will make his TV acting debut with a cameo on NBC‘s comedy “Parks and Recreation” as the celebrity crush of actress Amy Poehler‘s ditzy local councilwoman Leslie Knope, NBC said on Thursday.

Biden, 69, will play himself in the episode “Leslie vs. April,” airing November 15, where Knope, a city councilwoman for the fictional small town of Pawnee, Indiana, has a surprise meeting with the vice president in Washington D.C.

Knope has long described her ideal man as having the “brains of George Clooney and the body of Joe Biden.”

“Meeting Vice President Biden was a thrill for me and for Leslie,” Poehler said in a statement.

“He was a good sport and a great improviser. The vice president maintained his composure while I harassed him and invaded his personal space. The nation of ‘Parks and Rec’ will be forever grateful,” she added.

The scenes with Biden were shot in July in the chambers of the vice president’s ceremonial office, during the TV show’s recent trip to the nation’s capital to film scenes for this season’s storylines.

The biggest challenge of landing Biden’s cameo was keeping it a secret before Tuesday’s U.S. elections. Airing the episode prior to November 6 could have been equivalent to a campaign contribution to advertise a candidate, executive producer Michael Schur told Entertainment Weekly.

“Parks and Recreation” follows the Pawnee Parks department and its tireless deputy Knope, who puts all her efforts into improving her little hometown.

This is a big season for Poehler’s character, who is finally elected into city government, gets engaged to campaign advisor Ben Wyatt and meets her political heroes including Senators Barbara Boxer, Olympia Snow and John McCain, who were featured in September’s season premiere.

(Reporting By Piya Sinha-Roy, editing by Jill Serjeant)

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Democrats declare Obama the winner in Florida

MIAMI (Reuters) – Florida‘s Democratic Party declared victory for President Barack Obama in the closely divided battleground state on Thursday, as he clung to a narrow but apparently insurmountable lead in the glacially slow tallying of votes from Tuesday’s election.

If Obama wins Florida, it will add to his Electoral College margin and he will have won all of the key U.S. swing states except North Carolina, which he carried in 2008.

“On behalf of Florida Democrats, I wish President Barack Obama congratulations on his re-election and on his winning Florida’s 29 electoral votes,” Rod Smith, chairman of the Florida Democratic Party, said in a statement.

In a tacit concession, Republican Party of Florida spokesman Brian Burgess said in an email that he and other Romney supporters were “obviously not happy with the result” in the Sunshine State.

“But given the wave that we saw all over the country, we’re glad that we gave them enough of a fight in Florida to prolong the battle here as long as we did,” Burgess said.

As of Thursday evening, Obama had 49.92 percent of the statewide vote, versus 49.22 percent for Romney, according to the Florida Division of Elections.

Two of the three counties where ballots were still being tallied, Broward and Palm Beach, are heavily Democratic. The third county, Duval, has more registered Democrats than Republicans but has traditionally leaned Republican in presidential contests.

Just 58,055 votes separated the two candidates, but that was far more than in the 2000 election, when Republican George W. Bush won Florida by 537 votes and captured the White House after a recount dispute that reached the U.S. Supreme Court.

The slow-moving vote count in Florida has already made it the brunt of jokes on late-night television and conjured up ugly memories of the situation 12 years ago, when Florida was the cause of electoral gridlock.

This time, Florida seemed almost seemed irrelevant since Obama handily won re-election without its 29 electoral votes – the biggest prize of any of the nine key U.S. swing states.

HISPANICS FOR OBAMA

No officials were willing on Thursday to predict exactly when the race in the fourth most populous U.S. state, which has 67 counties, would be officially declared as decided. But barring any big surprises, Obama looked set to get a bump from Florida that would lift his electoral vote count to 332 over 206 for Romney.

“It’s appalling that two days after the election, Florida was not able to report our presidential election results,” Smith said in his statement.

“This embarrassment lays at the feet of Governor Rick Scott, who made a decision to cut early-voting in half and continually refused to extend early voting hours in light of the record turnout,” Smith said.

In comments earlier in Orlando, the Republican governor adamantly refused to accept responsibility for Florida’s failure to hold an election that was free of controversy.

Scott’s decision not to extend early voting, after it was cut back to eight days from 14 by the Republican-controlled legislature, has been cited by many Floridians as a cause of exceedingly long voter lines on Tuesday.

Scott told Reuters, “We did the right thing” when asked about the decision, which many saw as a move to blunt voter turnout for Obama.

The length of ballots, which included 11 proposed state constitutional amendments backed by the legislature, has also been blamed for long lines at polling places and delays in tallying final results. Scott said: “The amendments don’t go through the governor. The amendments only go through the legislature.”

Smith attributed Obama’s victory, at least in part, to what he described as “the strongest, largest ground game” Democrats had ever mounted in Florida, all part of a carefully calculated get-out-the vote effort.

The Obama campaign also cited a large turnout by the state’s 1.4 million Hispanics, who voted heavily for the president. Obama won a record 61 percent of Hispanic votes in Florida, up from 57 percent in 2008, according to exit polling data compiled by Bendixen & Amandi, research and media consultants for the Obama Hispanic campaign.

Democrats made surprising inroads in the Cuban-American community, capturing 48 percent of the traditionally conservative Cuban-American vote, according to Bendixen & Amandi, surpassing the 35 percent mark set by Democratic President Bill Clinton in 1996.

“This really is a sea change,” said Sergio Bendixen, a longtime Miami pollster. “The Cuban community is no different from anywhere else in the country. It is lower middle-class, it does not have health insurance and it wants to have it. It counts on Medicare and Social Security and it’s finally figured out which party is defending their interests.”

He said the growing population of 380,000 Puerto Ricans in central Florida was also pivotal. They preferred Obama over Romney by a margin of 83 percent to 17 percent.

(Additional reporting by David Adams in Miami, Barbara Liston in Orlando and Michael Peltier in Tallahassee; Editing by Philip Barbara and Peter Cooney)

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